I also assume you're rolling with the most popular dose of 5% strength 50mg/ml. Have experienced very noticeable results. Since then, similar studies on humans have not been conducted or published in peer-reviewed medical journals. It prevents miniaturization by blocking DHT, Testosterone, and other androgens from attaching to the hair follicle. Many of the stories published online are claims from individuals who may either have a conflict of interest or are already on other hair-loss medications such as minoxidil and finasteride. RU-58841 MezogenRX. By Bonnke Arunga, MBBS Updated on March 9, 2023 Reviewed by dermatologistDr. Suneil Gandhi, MD. This combination is pretty common, since many folks are using both, especially on cycle. You may not even get a genuine product to begin with. The products we offer are intended for . Airtight containers 7. Product shipped fast, has the right smell, and support is great. You can buy this in group buys or elsewhere (Kane, MPB Treatments) and mix RU in that. Next, pour the 50ml of K&B solution into the beaker with the 2.5 grams of RU58841 raw powder. New Release (2016). Be careful that it does not trickle down onto the forehead, sides of the face, and neck. These are more forgiving on sensitive scalps. 2) At the same time order off of eBay or Amazon a 0.001 gram digital scale. To briefly describe how it works, it is basically a turn-key all in one hair loss compound that blocks all DHT on the scalp, and can significantly improve the life of anybody experiencing hair loss, and Im shocked it isnt more heavily researched. I use a boar brush to exfoliate. Just like finasteride (but minus the side effects), the effects of RU58841 are as follows: The safety and effectiveness of RU58841 are quite impressive. Follicular regrowth with 5 -reductase inhibitor (finasteride) or androgen receptor blocker (RU58841) in the bald scalp of the stumptailed macaque. In general, most apply RU58841 as a topical agent (directly to the scalp) or digest it orally through a powder substance. Amazing quality product and even better customer service. Great customer service and fast delivery. RU58841 is stable for at least 2 years at room temperature. The goal of mixing is to bring out the best in your multi-track recording by adjusting levels, panning, and time-based audio effects ( chorus, reverb, delay ). Unfortunately, none of them are completely effective to restore your full head of hair. RU58841 is a watery formulation. I don't see the advantage tbh given that the liquid minoxidil isn't all that pricey and works out cheaper than buying the Ethanol, but I'm sure there are use cases for doing it without the Minoxidil due to side effects. They fixed right away without any question. After the measurement has stabilized, turn the scale back to 0 with the beaker still on it by pressing the Tare button. First is cheaper, second is more straightforward. So you have to apply it carefully on the scalp, behind the hairline, and spread it to cover the target area. However, as there have been no direct human studies for more than a decade, the FDA has not approved it for the management of any condition. Whats more, it may be an economic disadvantage to overuse your medication. This is known as a vehicle. Most of the purchases for RU58841 can be made online from several of the most popular suppliers like Chemyo, Kane, andAnagen Inc. This can only be done when RU is mixed into a solution like Everclear or KB and dissolved completely. It has been found to be well tolerated by the people using it, and not many side effects have been reported. Built-in Cover: Keep your electronic food scale safe with the built-in durable cover. DOI: Battmann, T., Bonfils, A., Branche, C., Humbert, J., Goubet, F., Teutsch, G., & Philibert, D. (1994). You should now have a cloudy solution of RU58841. The best way to reach us is by using our contact form. Reddit and its partners use cookies and similar technologies to provide you with a better experience. I can't seem to spread less than 2ml of RU on my scalp without missing spots. Will be a lifetime customer. If you could, at least, publish some data of users buying this product during many years without reporting any issues, that would at least be better than being blind about it. All my hair returned that I lost from taking testosterone replacement therapy (TRT). Nanoxidil for Hair Loss: Efficacy, Side-Effects, vs. Irrespective of how you store it, you should be careful not to expose it to high temperatures or sunlight, because these conditions will degrade the active compound and it may lose its effectiveness. I keep those sealed in several ziplock bags, in another closed container to ensure no water somehow seeps in and hits the powder. Written by Kartik Kumar Rathi Updated On February 1, 2023 Compound Summary Class of Compound Peptide (NSAA)/SARMs Mechanism of Action Offline. 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Before starting treatment, I thought shedding was androgen induced. I will caveat that per my RU58841 write-up, I don't recommend any DHT blocking/targeting/reducing compound unless also using exogenous test. AMAZING PRODUCT, GREAT SERVICE. The material published on hairverse.com is not intended as medical advice, diagnosis, or recommended treatment. These typically cost between $20-30 US, heres the one I use: http://i50.tinypic.com/23j28wn.jpg ProStrakan rebrands as Kyowa Kirin. The monkeys experienced an increase in hair growth of 103%, compared to just 88% for those given finasteride. US orders above $100 and International orders above $250 Qualify for free discreet shipping. RU58841 8% Highest Strength DHT Blocker - Shipping from Sweden 5 out of 5 stars (1) 310.00 SEK. A controlled study of the effects of RU58841, a nonsteroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosteroneconditioned nude mice. For more information, please see our Subscribe and get my 20 Underground Bodybuilding Secrets You Wont Find On Google E-Book 100% FREE, There are advantages and disadvantages to mixing your RU58841 with Minoxidil liquid, What You Will Need To Mix Your Own RU58841 And Minoxidil Combination Solutions, Adding The RU58841 Powder To The Minoxidil Liquid Solution, Cheaper if you already use Minoxidil liquid every day, Efficient as Minoxidil already comes in separate 60 ml bottles (very close to the standard 50ml PG + Ethanol solutions we use to measure and mix our RU58841, Requires that you use Minoxidil every single time you apply RU58841 because they are mixed. We also use third-party cookies that help us analyze and understand how you use this website. all in my family,Dad n Mum ,all Males are bald! Step 1: Measure out 3000mg (3 grams) of RU58841 raw powder per bottle of Minoxidil by weighing it out. Please Log in or Create an account to join the conversation. Doing so will improve its penetrative value and overall effectiveness. This category only includes cookies that ensures basic functionalities and security features of the website. Im excited to see what happens by the end of this bottle! Propylene Glycol (PG) (roughly $3.00 for 200ml) 4. This is out of an abundance of caution, mostly. The mechanism of RU58841 is entirely different from other anti-androgenic medications. Here the recipe/mixture that was sent to me by a supplier in China. Another factor you should be aware of is that the medication is not regulated by the FDA. Don't use more than 100mg *ever* although it's good to start off for the first month or so at a higher dosage like 100mg only to kickstart the whole process and any potential regrowth. Thus consult your doctor and consider other tried and tested options for hair loss, like minoxidil, oral or topical finasteride (the more widely used RU58841 alternative), or laser light devices, before considering this one. You deliver fast,perfect service,never any Problems etc.etc. If possible, consult your doctor or healthcare provider before you use this product, or when you notice symptoms after using it. Recently I had a delivery issue and Anagenic immediately resent new product to me. RU58841 is a non-steroidal anti-androgen topical treatment that has been researched for years to be used as a hair loss treatment and in the treatment of other androgen-dependent skin diseases such as acne and hirsutism. The raw powder form is a little cheaper and gives a bit more of flexibility. Suggestions? Highly recommended. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Only issue I see is lack of safety studies, specially long term. The purpose of this is so we can determine what 3 grams of RU5881 powder is without the beaker screwing up our measurement. As a result, you may want to apply it about 20-30 minutes after taking a shower. Even at high doses of up to 0.01 milligrams, the action was still limited to the site of application a much-desired relief for the researchers. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. It may cause skin irritation or allergy. They act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). e.g. A list of side effects would be useful. Eventually, one company ProStraken acquired the full rights to RU58841 and changed its name to PSK3841. All rights reserved. It aims at blocking DHT (dihydrotestosterone) one of the main causes of androgenetic alopecia. Very fast shipping and excellent product from anageninc. PLEASE FAMILIARIZE YOURSELF WITH OUR TERMS & CONDITIONS PRIOR TO ORDERING. Subscribe and get my 20 Underground Bodybuilding Secrets You Wont Find On Google E-Book 100% FREE. You'll need to scoop up the RU powder somehow. You should now have a cloudy solution of RU58841. Please if you do will you post them to let us see if this stuff works. Once you have made up your mind, choose the 99% pure grade while taking care to read the label carefully so that nothing is appearing out of place. It is important to store RU58841 in a dry, dark, and cool place as it degrades in heat and sunlight. This sebum reduces the penetrative value of RU58841. Phase 3. grunt master 46 subscribers 149 12K views 6 years ago Step 1: Get 99%+ plus RU58841 ( Curent batch is from https://www.chemyo.com/ru58841.html but. Scan this QR code to download the app now. It is used as a hair loss treatment, and gives you an aesthetic look! Been using 3 weeks on test subject. Hypothetically, lets say you want to make a 5% strength 50mg/ml RU58841 solution (the most popular dosage/strength). The phase 1 trial involved the application of 5% solution twice daily for 4 weeks, and the phase 2 trial compared the placebo to 2.5% and 5% solutions of RU58841 for 6 months. Your solution should end up looking completely clear. If it does, and you mix it with RU then the RU will not work. Bonnke Arunga is a senior medical student and an expert health writer. What also would be useful would be a list of side effects reported by long term users. Would a reliable member not be interested in packaging this up into monthly bundles with a small mark up and shipping to who ever signs up? RU58841 is a bit watery so it is best to apply within and behind the hairline. Please enable JavaScript in your browser to submit the form. Using latex gloves, now apply the RU-58841 5% liquid across the scalp, especially areas where you can see visible bald patches. If I see any new hairs I will increase my rating. Its a big myth that RU58841 is unstable at room temperature. Rats and hamsters were the animal models used to test its effectiveness. For now, information about its side effects can only be derived online from the reviews of customers who have actually used the product. Hairverse.com uses cookies to give you the most relevant experience by remembering your preferences and repeat visits. I'm talking the hard bristles. RU58841 Raw Powder Ethanol (Many People use Everclear (190 proof = 95%) Ethanol) Propylene Glycol A Very Accurate Digital Scale Glass Stirring Rod 2x 50ml Measuring Beakers 50ml+ Bottle To Hold Your RU58841 Solution A Funnel The Instructions First thing you want to do is grab a 50ml measuring beaker and fill it up with 35ml of Ethanol. Upload your video Will be ordering again. With Best Regards, Don't use more than 100mg *ever* although its good to start off for the first month or so at a higher dosage like 100mg only to kickstart the whole process and any potential regrowth. PLEASE FAMILIARIZE YOURSELF WITH OUR TERMS AND CONDITIONS PRIOR TO ORDERING. Since this medication is anti-androgen, it may be able to target androgen-dependent skin conditions such as acne and androgenic alopecia. Helping one another to deal with hair loss . This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. Privacy Policy. 4. Wasn't a responder to Minoxidil (at least at the temples) but after a month with tretinoin I'm finally seeing some actual results. Excellent customer service! All the benefits of DHT are left intact when you use RU58841. In simple terms they are the converse of steroidal antiandrogens (SAAs), which steroids that are structurally related to testosterone. It can easily be bought on Amazon, drug store/chemist and even some grocery stores. It works by countering the effects of DHT. Mixing RU58841 5% solution - The easy way! (There was a picture in the pdf that they sent me. So if this enters your bloodstream, it can lead to side effects such as fatigue, headache, dizziness, decreased libido, erectile dysfunction, chest pain, etc. Exposing RU58841 to light or higher temperatures will cause degradation of the compound. We have actually verified this by doing an HPLC stability test that showed that there was no significant degradation after 24 months at room temperature. De Brouwer, B., Tetelin, C., Leroy, T., Bonfils, A., & Van Neste, D. (1997). There you have it, now you have a 50ml 5% RU58841 K&B solution dosed at 50mg/ml. Privacy Policy. In studies and clinical trials RU58841 solution has shown to strongly compete against DHT at the androgen receptor. I find it rare for someones scalp to be irritated by the PG/Ethanol to the point of needing K&B instead as the carrier. If you already use Minoxidil liquid every day, you want to use RU58841, and your dose has consistently proved to be constant between the two compounds, you may be in the ideal position to use your Minoxidil liquid as your mixing solution for RU58841. The raw powder form is suited for those who want more control over the concentration, or want to mix it with minoxidil. Anageninc is top notch on quality and service. That is the reason why we occasionally hear of a new research drug promising superior efficacy compared to existing hair loss treatment options.One such research drug is RU58841. RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA). And arrives quickly most of the time! Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It may not display this or other websites correctly. Thank you for taking the time to make this, that is THE question . Then you can correctly measure 30-100mg of RU for each application. See this article for more information: https://www.propublica.org/article/the-myth-of-drug-expiration-dates. Get New Research, Treatments, and Discoveries Delivered to your Inbox. This seems pretty irrelevant if you don't. I got my package within 3 days. (1995). Add 3 grams of powder to the empty beaker on the scale until you see the scale reading 3 grams. So definitely anti androgen activity there. Other than that, it is really miraculous that it works after having failed with dutasteride. It was renamed after newer companies bought the rights to the original product, RU58841. ), from Maseno University. 0.001g Scale (roughly $30.00) 8. Hopefully this helps the noobies as well as some small tricks for old timers. As a result, the systemic side effects that occur due to lowered production of DHT are not seen, for example, sexual side effects. An example is enzulutamide which is structurally similar to RU58841 and is stable for a minimum of 2 years. Topical Finasteride for Hair Loss: Better than Oral? 2005. After dedicating over 8 years to extreme self-improvement, I have created "More Plates More Dates" as a one stop shop for helping you to get yourself on the right path to the "best you" possible too. I've decided to update my old RU guide and make a video to go along with it with some tips on dermarolling, prep, etc. Add 2.5 grams of powder to the empty beaker on the scale until you see the scale reading 2.5 grams. ''I have hope for life man'' - buckthorn, 2018. RU58841 is a topically applied anti-androgenic substance. I keep those sealed in several ziplock bags, in another closed container to ensure no water somehow seeps in and hits the powder. You must log in or register to reply here. Minoxidil is an antihypertensive vasodilator medication. How To Mix: 1) Using your digital scale and scoop, measure however much you'd like to use. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. It is an effort to improve information available to the users of /r/PEDs and will function as a type of skunkworks as we work on content and collaborate on research. Choose products you need for your research. For instance, several companies had acquired and dropped their right to this product. It is mandatory to procure user consent prior to running these cookies on your website. More on RU58841 here and addressing its mixed reputation. (30 seconds). Minoxidil. I am beyond pleased with this product and will recommend to anyone experience hair loss. Once you press this, it will reset the scale to 0 even with the beaker on it. IE; RU, SETI, etc. This is crazy but its only been about 1.5weeks since I started, kinda just stopped paying attention to the process, then just recently, noticed that my head feels more bristly. All you need to do now is get your glass stirring rod, and stir the solution until it is crystal clear and you cant see any fragments of unmixed RU58841 powder in it. FeartheLoss, how do you actually know that Ru degrades quickly? The concept of RU58841 is quite old. RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. It has been demonstrated to interrupt this hair loss message locally so that normal hair growth could continue. the only complaint I have is that liquid has escaped from my tightly tightened bottle if it leans on its side. My only complaint and reason for 4 stars, is that the batch date is sometimes well past 6+ Months, sometimes ranging to a Year. Videos Help others learn more about this product by uploading a video! Small bottles 6. It definitely works without a doubt. Seems to be working okay and rapidly with no side effects so far. It is hoped that future studies will document the side effects of using RU58841. RU58841 goes by several names. Been using the powder and mixing it with Alfatrdiol and Stemoxidine. Shake and swirl the solution lightly until the RU58841 powder has completely dissolved inside the bottle, and the solution is completely clear. Dermaroller 10. Also an idea of what we could expect in terms of results. Room temperature is the least ideal scenario, but if you dont have a fridge or freezer you can store it in, then at least make sure its in a cool, dry place, out of direct light when youre storing it at room temperature. It will keep your scale looking like new and protect it from scratches, bumps, and everyday wear and tear. Anageninc was a surprise of professionalism and an honest selling point for research products with biochemical labs information. 1. RU58841 complete guide, how to mix / apply / store - YouTube 0:00 / 17:18 RU58841 complete guide, how to mix / apply / store Odin's BS 296 subscribers Subscribe 20K views 2 years ago to. My package was lost by the local postal service, contacted anagen and they sent me a free replacement the next day! Been using it for 9 months. If you need to make 8% RU, you need to add 4.8 grams of RU. Once youve done that, you can turn off the scale and put it away. DHT blockers (oral) are one of the few treatments for androgenetic alopecia (male and female pattern hair loss) that is approved by the FDA. Shedding stopped almost immediately after starting treatment. RU58841 is a nonsteroidal anti-androgen for hair loss (androgenic alopecia). But based on the physiologic processes it undergoes, we can hypothesize on some of its potential side effects. No portion of this page may be duplicated without consent. Oral Minoxidil for Hair Loss: Better than Topical? A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice Human hair growth can be monitored for several months after the transplantation of scalp samples from men with androgen-dependent alopecia on to female nude mice. In studies and clinical trials RU58841 has shown to; Strongly compete against DHT Increase cellular replication rate in the matrix cells Necessary cookies are absolutely essential for the website to function properly. Great service, shipped immediately. Less than 100mg I'm safe from sides. Scan this QR code to download the app now. Essentially, to prevent degradation of the compound, you simply must make sure it's stored out of any direct light and it's in a cold enough temperature. Posts: 3384. I have been researching the product for 3 years with good maintenance research results. This is a quick write-up on how to make your own Minoxidil / RU58841 formula, prompted by a question from u/PopBottlesPopHollows. Getting everything in bulk would reduce the cost.. What is the reason(s) you don't just dump it in minoxidil? Thank you for your perfect informative post. The overall effect is really noticeable as can be seen in this RU58841 before and after comparison below. Creatine occurs naturally in the human body. For a better experience, please enable JavaScript in your browser before proceeding. Do you have any pictures of your hair from using this stuff. /r/tressless , 2023-03-16, 12:16:40 In studies and clinical trials RU58841 has shown to; Strongly compete against DHT Increase cellular replication rate in the matrix cells Copyright 2022 More Plates More Dates All Rights Reserved. New comments cannot be posted and votes cannot be cast. RU58841 | RU-58841 Solution 50mg/ml - 50ml. It is also known as PSK-3841 . 2% Formulation. RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. Impressed! So I've been on RU58841 since late November and I don't think it's helped my hairline out. The problem is that any treatment which reduces DHT, usually by inhibiting 5-alpha-reductase (drugs like Finasteride), can cause side effects around the body. RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen. It blocks androgens from binding, such as DHT. When you look at studies about the stability of other various compounds you can actually also see that a lot of them are perfectly stable for a long time. All that is required with the K&B solution is to pour your desired amount of RU58841 powder into the premixed K&B solution, then shake or stir lightly until it is thoroughly dissolved and mixed evenly. As a result, you should actively think through it and decide if it is indeed the medication you want. This is the reason why it is advisable that you use RU58841 with caution. If you dont already know what RU58841 is, it is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness). It was renamed after newer companies bought the rights to the original product, RU58841. Ive only been using for 2 weeks so cant provide a 5 star rating, yet. Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque.
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